🦠 Digestive Health

🔭 Scientific Evidence

Pro-Kolin Advanced has the strongest direct clinical evidence of any canine digestive paste. A randomised, double-blind, placebo-controlled trial of 148 dogs with acute diarrhoea across UK and Ireland veterinary practices — published in the Journal of Veterinary Internal Medicine (2019) — found diarrhoea resolved 1.6× faster in the Pro-Kolin group vs placebo (P=0.02), with fewer dogs requiring additional medical intervention. An earlier controlled trial of 51 dogs also showed faster return to normal faecal consistency. The formula combines Enterococcus faecium 4b1707 (a registered EU probiotic strain), Preplex prebiotic, kaolin and montmorillonite clay (natural gut soothing agents), psyllium fibre, pectin and beta-glucans. One caveat: both studies were funded by ADM Protexin Ltd, who manufacture the product — independent replication would further strengthen the evidence.

📚 Research References

• Nixon SL, Rose L, Muller AT (2019) — Randomised, double-blind, placebo-controlled trial, 148 dogs with acute diarrhoea, UK and Ireland. Journal of Veterinary Internal Medicine, 33(3):1286-1294
• Protexin Veterinary (2015) — Controlled trial of Pro-Kolin+ for acute diarrhoea, 51 dogs, Spain. Published in Protexin clinical study report
• Scahill K et al. — Meta-analysis of probiotics/prebiotics/synbiotics in canine acute diarrhoea supporting E. faecium strains

🔭 Scientific Evidence

FortiFlora contains Enterococcus faecium SF68, the most extensively studied probiotic strain in veterinary medicine. A 2003 Journal of Nutrition study demonstrated that puppies fed SF68 showed significantly enhanced immune function and maintained vaccine-specific antibodies longer than controls. A 2011 randomised shelter study showed dogs receiving SF68 experienced fewer diarrhoea episodes vs placebo. A 2012 trial on Alaskan sled dogs found SF68 significantly reduced both the number and severity of diarrhoea days vs placebo. A 2017 randomised clinical trial confirmed SF68 was effective alongside metronidazole for treating shelter dogs with diarrhoea. Proprietary microencapsulation ensures the bacteria survive stomach acid and reach the intestinal tract. The No.1 veterinarian-recommended dog probiotic brand in the UK and US.

📚 Research References

• Benyacoub J et al. (2003) — Supplementation with E. faecium SF68 stimulates immune functions in young dogs. Journal of Nutrition, 133(4), 1158-1162 (PubMed 12672936)
• Bybee SN et al. (2011) — Effect of E. faecium SF68 on diarrhoea in shelter dogs and cats. Journal of Veterinary Internal Medicine, 25:856-860
• Gore AM & Reynolds A (2012) — Effects of E. faecium SF68 on stress diarrhoea in Alaskan sled dogs. ACVIM Forum Proceedings
• Fenimore A et al. (2017) — Evaluation of metronidazole with and without E. faecium SF68 in shelter dogs with diarrhoea. Topics in Companion Animal Medicine, 32:100-103

🔭 Scientific Evidence

YuMOVE Digestive Care contains Enterococcus faecium NCIMB 10415 E1707 — the same EU-registered probiotic strain used in Pro-Kolin Advanced and FortiFlora, which has multiple published canine clinical trials supporting its efficacy for gut health and diarrhoea management. The formula also contains ActivBio™ — a proprietary prebiotic complex of MOS, scFOS and Beta-glucans — which work together to block bad bacteria and feed beneficial gut flora. No product-specific published clinical trial exists for YuMOVE Digestive Care itself, distinguishing it from Pro-Kolin Advanced which has its own peer-reviewed JVIM study. However the ingredient evidence is solid. From Lintbells, the same trusted UK brand behind the clinically-tested YuMOVE joint supplement range.

📚 Research References

• Nixon SL et al. (2019) — E. faecium 4b1707 strain clinical trial, 148 dogs with acute diarrhoea, JVIM 33(3):1286-1294 (same probiotic strain)
• Bybee SN et al. (2011) — E. faecium SF68 reduces diarrhoea in shelter dogs. Journal of Veterinary Internal Medicine, 25:856-860 (related E. faecium strain evidence)
• EFSA (2012) — Scientific opinion on E. faecium NCIMB 10415 safety and efficacy as a feed additive for dogs and cats

🔭 Scientific Evidence

Pro-Fibre is a daily high-fibre supplement combining prebiotics and a clinically proven postbiotic (Bifidobacterium animalis subsp. lactis CECT 8145, branded Priome® MH) with high-quality dietary fibres including psyllium husk and sugar beet pulp. The postbiotic strain has published clinical evidence supporting its role in supporting a healthy gut microbiome. Psyllium is well-evidenced for stool firming and improving bowel regularity in dogs. However no product-specific published canine clinical trial exists for Pro-Fibre itself — distinguishing it from Pro-Kolin Advanced which has its own peer-reviewed JVIM study. From Protexin, the UK's No.1 veterinary digestive supplement manufacturer by value. Recommended by 9 out of 10 UK vets. Particularly effective for anal gland issues due to the stool-bulking effect of high fibre content.

📚 Research References

• Priome® MH — Bifidobacterium animalis subsp. lactis CECT 8145 postbiotic strain with published clinical evidence for gut microbiome support
• Rabbani GH et al. — Psyllium (Plantago ovata) fibre evidence for stool firming and bowel regularity across species
• Protexin Veterinary — UK No.1 veterinary digestive supplement manufacturer (Kynetec VetTrak, MAT Sept 2025)