🦴 Joint Supplements

🔭 Scientific Evidence

YuMOVE has been tested in a real-world clinical study conducted on live dogs by the Royal Veterinary College (RVC) in the UK — one of the most respected veterinary institutions in the world. A double-blind, placebo-controlled study is the gold standard in clinical research, meaning neither the dogs' owners nor the researchers knew which dogs were receiving the supplement or the placebo, eliminating bias. The study demonstrated measurable improvements in joint mobility within 6 weeks in the majority of treated dogs. The key active ingredient, ActivEase Green Lipped Mussel (GLM), provides a concentrated combination of Omega-3 fatty acids, Chondroitin, and Glucosamine. GLM-based supplements have the strongest scientific evidence base of any joint supplement ingredient for dogs, supported by multiple independent studies. Additional ingredients include Hyaluronic Acid, plant-based Glucosamine, and antioxidant Vitamins C and E.

📚 Research References

• Royal Veterinary College UK — Double-blind, placebo-controlled, objectively measured clinical study on live dogs (cited by Lintbells/YuMOVE)
• Rialland P et al. (2013) — Effect of a diet enriched with green-lipped mussel on pain behaviour and functioning in dogs with clinical osteoarthritis. Canadian Journal of Veterinary Research
• Hielm-Björkman A et al. (2012) — Evaluating complementary therapies for canine osteoarthritis. PLOS ONE
• Bui LM & Bierer TL (2003) — Influence of Green Lipped Mussels on pain behavior and functioning in dogs with arthritis. Veterinary Therapeutics

🔭 Scientific Evidence

Pure salmon oil is one of the most scientifically supported joint supplements available for dogs. Unlike most joint supplements, fish oil Omega-3 fatty acids (EPA and DHA) have been tested in multiple large, independent, randomised, double-blind, placebo-controlled clinical trials — the gold standard of medical research. A study published in the Journal of the American Veterinary Medical Association found that 82% of dogs fed fish oil Omega-3s showed measurable improvement in how they moved and bore weight, compared to just 38% in the control group. A multicenter trial of 127 dogs across 18 veterinary clinics confirmed significant improvements in joint pain and mobility over 6 months. A further trial of 78 dogs showed that all measures of discomfort, lameness, and joint severity significantly improved versus placebo after 84 days. Cornell University recommends fish oil as a first-line supplement for joint health. The American Animal Hospital Association (AAHA) also recommends Omega-3 fatty acids as a first-tier joint treatment. Pets Purest Scottish Salmon Oil is a pure, high-quality source of EPA and DHA with no additives.

📚 Research References

• Fritsch DA et al. (2010) — Evaluation of the effects of dietary supplementation with fish oil omega-3 fatty acids on weight bearing in dogs with osteoarthritis. Journal of the American Veterinary Medical Association, 236(1)
• Fritsch DA et al. (2010) — Multicenter veterinary practice assessment of the effects of omega-3 fatty acids on osteoarthritis in dogs. Journal of the American Veterinary Medical Association, 236(1)
• Mehler SJ et al. (2016) — A prospective, randomized, double-blind, placebo-controlled evaluation of the effects of EPA and DHA on clinical signs of osteoarthritis in dogs. Prostaglandins, Leukotrienes and Essential Fatty Acids
• Cornell University College of Veterinary Medicine — Recommends fish oil as a first-line supplement for canine joint health
• American Animal Hospital Association (AAHA) — Recommends Omega-3 fatty acids as a first-tier treatment for canine osteoarthritis

🔭 Scientific Evidence

Dasuquin stands apart from standard glucosamine and chondroitin supplements through the addition of ASU (Avocado/Soybean Unsaponifiables) — an ingredient with direct canine structural evidence. A controlled study by Boileau et al. (2009) demonstrated that ASU significantly reduced cartilage damage and bone lesions in dogs with surgically induced osteoarthritis compared to a placebo group — this is structural evidence, not just symptom relief. A further published study showed that Dasuquin produced improvements in mobility and weight-bearing in dogs with chronic osteoarthritis similar to those achieved with prescription anti-inflammatory drugs. Cornell University College of Veterinary Medicine specifically recommends Dasuquin over standard Cosequin. Nutramax report over 80 published peer-reviewed papers supporting the ingredients in Dasuquin. Note: Dasuquin is not suitable for dogs with soy allergies as ASU contains soy derivatives.

📚 Research References

• Boileau C et al. (2009) — Protective effects of ASU on structural changes in experimental dog osteoarthritis. Arthritis Research & Therapy, 11(2), R41
• McCarthy G et al. — Dasuquin efficacy may be similar to NSAIDs in dogs. dvm360 (sponsored by Nutramax Laboratories)
• Vandeweerd JM et al. (2012) — Systematic review of efficacy of nutraceuticals to alleviate clinical signs of osteoarthritis in dogs. Journal of Veterinary Internal Medicine
• Cornell University College of Veterinary Medicine — How joint supplements can help with orthopedic conditions (specifically recommends Dasuquin)

🔭 Scientific Evidence

Nutramax claim Cosequin is backed by peer-reviewed, published, controlled US veterinary studies using their proprietary FCHG49 Glucosamine and TRH122 Chondroitin specifications. However the available published research is primarily absorption studies — confirming the ingredients reach the bloodstream — rather than clinical outcome trials demonstrating measurable improvement in dogs with osteoarthritis. One independent study published in the Veterinary Record found no significant improvement in dogs receiving Cosequin versus placebo. Cornell University specifically recommends Nutramax's stronger product Dasuquin over standard Cosequin. The science score reflects mixed independent clinical evidence. Cosequin does not contain ASU or Green Lipped Mussel, which have the strongest independent evidence base for canine joint health.

📚 Research References

• Nutramax Laboratories — Peer-reviewed published controlled US veterinary studies on FCHG49 and TRH122 specifications (bioavailability studies)
• Innes JF et al. (2003) — Randomised double-blind placebo-controlled study of joint supplement in dogs with osteoarthritis. Veterinary Record
• Vandeweerd JM et al. (2012) — Systematic review of efficacy of nutraceuticals to alleviate clinical signs of osteoarthritis in dogs. Journal of Veterinary Internal Medicine
• Cornell University College of Veterinary Medicine — Recommends fish oil and Dasuquin over standard Cosequin

🔭 Scientific Evidence

MobilityMax contains a blend of ingredients that individually have varying levels of scientific support, but no independent peer-reviewed clinical trial has been published specifically testing MobilityMax as a complete product. The science score is based on ingredient-level evidence. A 2022 PLOS ONE randomised, placebo-controlled trial of 40 dogs with osteoarthritis found that a supplement containing Glucosamine, Chondroitin and Hyaluronic Acid produced significant improvements in pain and mobility scores versus placebo — ingredients present in MobilityMax. However, a 2024 review of multiple studies noted that Glucosamine and Chondroitin alone show weaker results than Omega-3 based supplements such as Green Lipped Mussel. MSM has limited high-quality canine trial data but is generally considered safe. The absence of Green Lipped Mussel or concentrated fish oil is a notable gap compared to the strongest-evidence joint supplements.

📚 Research References

• Comblain F et al. (2022) — A randomised, double-blind, placebo-controlled trial of a dietary supplement in dogs with osteoarthritis. PLOS ONE
• Vandeweerd JM et al. (2012) — Systematic review of efficacy of nutraceuticals to alleviate clinical signs of osteoarthritis in dogs. Journal of Veterinary Internal Medicine
• Rialland P et al. (2013) — Effect of a diet enriched with green-lipped mussel on pain behaviour in dogs with clinical osteoarthritis. Canadian Journal of Veterinary Research
• Colitti M et al. (2012) — Transcriptome modification of white blood cells after dietary curcumin supplementation in dogs. Veterinary Immunology and Immunopathology

🔭 Scientific Evidence

Pooch & Mutt Joint Care contains Green Lipped Mussel (GLM), Glucosamine, Chondroitin, Hyaluronic Acid, MSM and Collagen — a well-constructed combination of ingredients. No independent peer-reviewed clinical trial has been published specifically testing this Pooch & Mutt product. However GLM, the standout ingredient, has a strong body of independent clinical evidence. A 2013 study in the Canadian Journal of Veterinary Research (Rialland et al.) found significant improvement in how dogs moved and bore weight — considered the gold standard measure of joint improvement — in dogs fed a GLM-enriched diet over 60 days. Multiple studies have verified GLM helps dogs with arthritis and Cornell University confirms this. The addition of Collagen is a relatively new ingredient with emerging positive evidence in human studies and limited but promising canine data. The science score reflects good ingredient-level evidence for the GLM and glucosamine/chondroitin combination, with no product-specific double-blind trial.

📚 Research References

• Rialland P et al. (2013) — Effect of a diet enriched with green-lipped mussel on pain behaviour and functioning in dogs with clinical osteoarthritis. Canadian Journal of Veterinary Research
• Bui LM & Bierer TL (2003) — Influence of Green Lipped Mussels in alleviating signs of arthritis in dogs. Veterinary Therapeutics, 4(4), 397-407
• Hielm-Björkman A et al. (2009) — Evaluating complementary therapies for canine osteoarthritis: Green-Lipped Mussel. Evidence-Based Complementary and Alternative Medicine
• Cornell University College of Veterinary Medicine — Multiple studies have verified Green Lipped Mussel helps dogs with arthritis